Our Science

RNAi, a sustainable path towards curative therapies

What is RNA interference (RNAi)?

RNAi is a gene-silencing process by suppressing the mRNA-protein translation via RISC (RNA Induced Silencing Complex). This process is triggered by double stranded RNA (dsRNA). Long dsRNAs from intrinsic or external source are cut by dicer enzyme into short (~21 nucleotides) duplexed nucleotides. These small fragments, referred to as small interfering RNAs (siRNA), constitute the RNA-induced silencing complex (RISC) and leads to the cleavage of the target mRNA. siRNA can be synthesized chemically and introduced to cytoplasm, which share the same mechanism of RISC.

Advantage of RNAi therapeutics
  • Rapid therapeutic discovery process

  • Rational drug design for any gene

  • Theoretically "limitless" repertoire of any previously non-druggable target 

  • Uses an efficient cellular process innate in any cell

  • Long-lasting efficacy

  • Possibility of targeting multiple genes in one therapeutic formulation

SAMiRNA™ is an IP protected RNAi platform that overcomes current key challenges

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SAMiRNA combines the conjugation and nanoparticle encapsulation strategies by doubly-conjugating RNAi with hydrophilic and hydrophobic modular components, resulting in self-assembling nanoparticle design ideal for optimizing delivery

RNAi Platform-driven Pipeline

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