PIPELINE

SRN001

IPF

What Is Idiopathic Pulmonary Fibrosis?

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disease where the lung tissue thickens and stiffens, making it difficult to breathe. The scarring (fibrosis) that develops is permanent and worsens over time. While there is no known cause for IPF, it often affects people around 70-75 years old.

► IPF is a type of interstitial lung disease where scar tissue builds up in the lungs. This scar tissue makes the lungs stiffer and harder to expand, hindering oxygen transfer to the bloodstream.

► There is currently no cure for IPF, but treatments can help manage symptoms and slow down the progression of the disease, such as antifibrotic medications.

► IPF is progressive, meaning the scarring and damage worsen over time.

► Average survival is 3 to 5 years, but some people live much longer. A lung transplant can also change your life expectancy.

DKD

What Is Diabetic Kidney Disease?

Diabetic kidney disease, also known as diabetic nephropathy, is a serious complication of diabetes that causes the kidneys to lose their ability to filter waste and excess fluid from the blood. It's a leading cause of chronic kidney disease and end-stage renal disease, requiring dialysis or transplantation.

How common is diabetic kidney disease?

Diabetic kidney disease is common. Around 30 to 40% of people with diabetes (both type 1 diabetes and type 2 diabetes) develop some form of diabetic kidney disease.
Diabetic kidney disease is actually the most common cause of kidney failure in the UK. Around one in five people needing dialysis have diabetic kidney disease, and this will probably increase in future.

What are the possible complications?

End-stage kidney failure

Diabetic kidney disease can sometimes lead to kidney failure, or end-stage kidney disease. End-stage kidney disease is when the kidneys are no longer able to function well enough to keep someone alive. The only treatments are dialysis or a kidney transplant

Cardiovascular diseases

All people with diabetes have an increased risk of developing cardiovascular diseases, such as heart disease, stroke and peripheral arterial disease. If you have diabetes and diabetic kidney disease, your risk of developing cardiovascular diseases is increased further. The worse the kidney disease, the further increased the risk.

High blood pressure

Kidney disease has a tendency to increase blood pressure. In addition, increased blood pressure has a tendency to make kidney disease worse.

HNSCC

What are cancers of the head and neck?

Cancers that are known collectively as head and neck cancers usually begin in the squamous cells that line the mucosal surfaces of the head and neck (for example, those inside the mouth, throat, and voice box). These cancers are referred to as squamous cell carcinomas of the head and neck. Head and neck cancers can also begin in the salivary glands, sinuses, or muscles or nerves in the head and neck, but these types of cancer are much less common than squamous cell carcinomas.

01 - HNSCC

How common are head and neck cancers?

Head and neck cancers account for nearly 4% of all cancers in the United States. These cancers are more than twice as common among men as they are among women. Head and neck cancers are also diagnosed more often among people over age 50 than they are among younger people. Researchers estimated that more than 68,000 men and women in the United States would be diagnosed with head and neck cancers in 2021

What are the possible complications?

End-stage kidney failure

Diabetic kidney disease can sometimes lead to kidney failure, or end-stage kidney disease. End-stage kidney disease is when the kidneys are no longer able to function well enough to keep someone alive. The only treatments are dialysis or a kidney transplant

Cardiovascular diseases

All people with diabetes have an increased risk of developing cardiovascular diseases, such as heart disease, stroke and peripheral arterial disease. If you have diabetes and diabetic kidney disease, your risk of developing cardiovascular diseases is increased further. The worse the kidney disease, the further increased the risk.

High blood pressure

Kidney disease has a tendency to increase blood pressure. In addition, increased blood pressure has a tendency to make kidney disease worse.