siRNAgen Therapeutics offers an end-to-end solution encompassing candidate sequence design, synthesis, and efficacy evaluation.
We identify and provide the most efficient candidate compounds targeting your gene of interest,
accompanied by a comprehensive experimental report detailing material information, testing methods, procedures, and all relevant data. We are offering our customized RNAi drug high-throughput screening service.
1. Save Time and Cost
By conducting synthesis as well as both in vitro and in vivo efficacy evaluations in one place, you can significantly reduce both time and costs.
2. High throughput screening
Fast and accurate results are achieved through high-throughput screening using the ExiPrep™ 96 Lite automated nucleic acid extraction system and the Exicycler™ 384 Real-Time Quantitative Thermal Block for 384-well RT-qPCR.
3. Expertise in siRNA Drug Development
We possess extensive know-how in siRNA drug development, ensuring reliable and effective research outcomes.
| Name | Content |
|---|---|
| Design & synthesis | Naked/Modified siRNA: On sequences between human and monkey by default. You can add animals such as mouse, rat, etc. |
| In vitro screening (RT-qPCR) |
Screening experiment setup Obtain suitable primers and cell lines for the experiment. |
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1st round screening: Screening all drug candidates |
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2nd round screening: Screening the top candidates for selection |
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3rd round screening: Top 5 candidates for IC50 testing |
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| Other |
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* All assays are performed in triplicate for both biological and technical replicates.
If you contact us(orders@sirnagen.com), we will promptly provide you with information on the experiment design and a quotation.
If you are interested in utilizing our SAMiRNA™ platform, please contact us for further information.